The effects of topical honey dressing versus silver sulfadiazine dressing for the treatment of burn wounds contaminated by Pseudomonas aeruginosa

AUTHORS

Shokrollah Hoseinzadeh 1 , Mahmoud Reza Miri 1 , * , Elham Jafari 1

AUTHORS INFORMATION

1 Qazvin university of medical sciences, Qazvin, Iran

How to Cite: Hoseinzadeh S , Miri M R, Jafari E . The effects of topical honey dressing versus silver sulfadiazine dressing for the treatment of burn wounds contaminated by Pseudomonas aeruginosa, Int J Health Life Sci. 2016 ; 2(2):e74159.

ARTICLE INFORMATION

International Journal of Health and Life Sciences: 2 (2); e74159
Published Online: December 10, 2016
Article Type: Research Article
Received: August 22, 2016
Accepted: December 12, 2016

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Abstract

The management of microbial contamination of burns in order to prevent sepsis is a routine requirement of acute care that led to the development of different therapeutic agents for topical use. This study was performed with the aim to compare the effects of topical honey dressing versus silver sulfadiazine dressing for the treatment of burn wounds contaminated by Pseudomonas aeruginosa. This animal study was performed in the central laboratory of Zahedan University of Medical Sciences in 2014. A total of 40 Hindi pigs were randomly divided into two groups of honey and silver sulfadiazine. After six hours of the inoculation of 108 Pseudomonas aeruginosa in the area of burn wound, in the honey group, the wound was dressed with honey, and in the silver sulfadiazine group, the wound was dressed with silver sulfadiazine. Then, after 30 daily dressings, the extent of the remaining wound was measured, and the results were compared between two groups. A P < 0.05 was considered significant. The honey group had less mortality than the silver sulfadiazine group (30% vs. 40%). Within 10 days, more granulation tissue was formed in the honey group than in the silver sulfadiazine group (90% vs. 20%). The extent of the remaining wound was significantly smaller in the honey group than in the silver sulfadiazine group (the percentage by which the wound shrunk was 74% in the honey group vs. 29% in the silver sulfadiazine group). The honey group had less contamination than the silver sulfadiazine group (20% vs. 95% at the 10th days of dressing). The honey dressing was shown to be significantly more effective than the silver sulfadiazine dressing for the treatment of burn wounds.

Keywords

Silver sulfadiazine Honey Burn wounds Pseudomonas aeruginosa Treatment

© 2016, International Journal of Health and Life Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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